6Z7F

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-(2-(1H-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide

This is a non-PDB format compatible entry.

Summary for 6Z7F

• Entry DOI: 10.2210/pdb6z7f/pdb
• Descriptor: Bromodomain-containing protein 2, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14147.26

Authors

Chung, C. (deposition date: 2020-05-30, release date: 2020-07-29, Last modification date: 2020-09-23)

• Primary citation: Preston, A.,Atkinson, S.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Jones, E.J.,Lindon, M.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Seal, J.,Taylor, S.,Wall, I.,Watson, R.J.,Woolven, J.,Demont, E.H.; Design and Synthesis of a Highly Selective andIn Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins.; J.Med.Chem., 63:9070-9092, 2020; PubMed: 32691591; DOI: 10.1021/acs.jmedchem.0c00605

Experimental method

X-RAY DIFFRACTION (1.605 Å)