6YVS
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 5-{4-[(Pyridin-3-ylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one
Summary for 6YVS
Entry DOI | 10.2210/pdb6yvs/pdb |
Descriptor | Focal adhesion kinase 1, 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | protein tyrosine kinase, atp binding, transferase, transferase-inhibitor complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 130914.38 |
Authors | Musil, D.,Heinrich, T.,Amaral, M. (deposition date: 2020-04-28, release date: 2021-02-10, Last modification date: 2024-01-24) |
Primary citation | Berger, B.T.,Amaral, M.,Kokh, D.B.,Nunes-Alves, A.,Musil, D.,Heinrich, T.,Schroder, M.,Neil, R.,Wang, J.,Navratilova, I.,Bomke, J.,Elkins, J.M.,Muller, S.,Frech, M.,Wade, R.C.,Knapp, S. Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chem Biol, 28:686-, 2021 Cited by PubMed: 33497606DOI: 10.1016/j.chembiol.2021.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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