6YD4

X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Canavanine-Amba

Summary for 6YD4

• Entry DOI: 10.2210/pdb6yd4/pdb
• Descriptor: Furin, 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Canavanine-Amba, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: protease, inhibitor, complex, canavanine, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 53372.93

Authors

Dahms, S.O. (deposition date: 2020-03-20, release date: 2021-02-17, Last modification date: 2024-01-31)

• Primary citation: Lam van, T.V.,Heindl, M.R.,Schlutt, C.,Bottcher-Friebertshauser, E.,Bartenschlager, R.,Klebe, G.,Brandstetter, H.,Dahms, S.O.,Steinmetzer, T.; The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.; Acs Med.Chem.Lett., 12:426-432, 2021; PubMed: 33732412; DOI: 10.1021/acsmedchemlett.0c00651

Experimental method

X-RAY DIFFRACTION (1.7 Å)