6YAW

Crystal structure of human GSTA1-1 bound to the glutathione adduct of cinnamaldehyde

Summary for 6YAW

Entry DOI	10.2210/pdb6yaw/pdb
Descriptor	Glutathione S-transferase A1, (2~{S})-2-azanyl-5-[[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-3-[(1~{R})-3-oxidanylidene-1-phenyl-propyl]sulfanyl-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	glutathione transferase, detoxification, metabolism, olfaction, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	52403.40
Authors	Schwartz, M.,Neiers, F. (deposition date: 2020-03-13, release date: 2020-08-26, Last modification date: 2024-01-24)
Primary citation	Schwartz, M.,Menetrier, F.,Heydel, J.M.,Chavanne, E.,Faure, P.,Labrousse, M.,Lirussi, F.,Canon, F.,Mannervik, B.,Briand, L.,Neiers, F. Interactions Between Odorants and Glutathione Transferases in the Human Olfactory Cleft. Chem.Senses, 45:645-654, 2020 Cited by PubMed: 32822468 DOI: 10.1093/chemse/bjaa055 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation