6YAA

Structure of the (SR) Ca2+-ATPase bound to the inhibitor compound CAD204520 and TNP-ATP

Summary for 6YAA

• Entry DOI: 10.2210/pdb6yaa/pdb
• Descriptor: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE, 4-[2-[(2~{R})-2-[3-propyl-6-(trifluoromethyloxy)-1~{H}-indol-2-yl]piperidin-1-yl]ethyl]morpholine, ... (4 entities in total)
• Functional Keywords: p-type atpase, inhibitory complex, calcium-transporting atpase, hydrolase
• Biological source: Oryctolagus cuniculus (Rabbit)
• Total number of polymer chains: 1
• Total formula weight: 110799.46

Authors

Heit, S.,Marchesini, M.,Gherli, A.,Montanaro, A.,Patrizi, L.,Sorrentino, C.,Pagliaro, L.,Rompietti, C.,Kitara, S.,Olesen, C.E.,Moller, J.V.,Savi, M.,Bocchi, L.,Vilella, R.,Rizzi, F.,Baglione, M.,Rastelli, G.,Loiacona, C.,La Starza, R.,Mecucci, C.,Stegmair, K.,Aversa, F.,Stilli, D.,Lund Winther, A.M.,Sportoletti, P.,Dalby-Brown, W.,Roti, G.,Bublitz, M. (deposition date: 2020-03-11, release date: 2020-05-20, Last modification date: 2024-01-24)

• Primary citation: Marchesini, M.,Gherli, A.,Montanaro, A.,Patrizi, L.,Sorrentino, C.,Pagliaro, L.,Rompietti, C.,Kitara, S.,Heit, S.,Olesen, C.E.,Moller, J.V.,Savi, M.,Bocchi, L.,Vilella, R.,Rizzi, F.,Baglione, M.,Rastelli, G.,Loiacono, C.,La Starza, R.,Mecucci, C.,Stegmaier, K.,Aversa, F.,Stilli, D.,Lund Winther, A.M.,Sportoletti, P.,Bublitz, M.,Dalby-Brown, W.,Roti, G.; Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia.; Cell Chem Biol, 27:678-, 2020; PubMed: 32386594; DOI: 10.1016/j.chembiol.2020.04.002

Experimental method

X-RAY DIFFRACTION (3.4 Å)