6XY2

Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody

Summary for 6XY2

• Entry DOI: 10.2210/pdb6xy2/pdb
• Descriptor: Cytotoxic T-lymphocyte protein 4, Heavy chain, Light chain, ... (4 entities in total)
• Functional Keywords: ctla-4, fab, antibody, immunnotherapy, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 63503.82

Authors

Gao, H.,Zhou, A. (deposition date: 2020-01-29, release date: 2020-12-09, Last modification date: 2024-10-09)

• Primary citation: Gao, H.,Cai, H.,Liu, J.,Wang, X.,Zheng, P.,Devenport, M.,Xu, T.,Dou, F.,Liu, Y.,Zhou, A.; Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody.; Cell Discov, 6:79-79, 2020; PubMed: 33298884; DOI: 10.1038/s41421-020-00202-9

Experimental method

X-RAY DIFFRACTION (3.05 Å)