6XN9
Solution NMR structure of recifin, a cysteine-rich tyrosyl-DNA Phosphodiesterase I modulatory peptide from the marine sponge Axinella sp.
Summary for 6XN9
Entry DOI | 10.2210/pdb6xn9/pdb |
NMR Information | BMRB: 30767 |
Descriptor | Recifin modulatory peptide (1 entity in total) |
Functional Keywords | cystine-rich peptide, protein knot, tyrosyl-dna phosphodiesterase i inhibitor, marine natural product, toxin |
Biological source | Axinella sp. 1 TF-2017 |
Total number of polymer chains | 1 |
Total formula weight | 4924.44 |
Authors | Schroeder, C.I.,Rosengren, K.J.,O'Keefe, B.R. (deposition date: 2020-07-02, release date: 2021-02-10) |
Primary citation | Krumpe, L.R.H.,Wilson, B.A.P.,Marchand, C.,Sunassee, S.N.,Bermingham, A.,Wang, W.,Price, E.,Guszczynski, T.,Kelley, J.A.,Gustafson, K.R.,Pommier, Y.,Rosengren, K.J.,Schroeder, C.I.,O'Keefe, B.R. Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I. J.Am.Chem.Soc., 142:21178-21188, 2020 Cited by PubMed: 33263997DOI: 10.1021/jacs.0c10418 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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