6XE7
Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 2-((2-formyl-3-hydroxyphenoxy)methyl)nicotinate
Summary for 6XE7
Entry DOI | 10.2210/pdb6xe7/pdb |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total) |
Functional Keywords | hemoglobin, antisickling, aromatic aldehyde, allosteric effector, oxygen transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 65205.66 |
Authors | Pagare, P.P.,Safo, M.K.,Musayev, F.N. (deposition date: 2020-06-12, release date: 2020-12-02, Last modification date: 2023-10-18) |
Primary citation | Pagare, P.P.,Ghatge, M.S.,Chen, Q.,Musayev, F.N.,Venitz, J.,Abdulmalik, O.,Zhang, Y.,Safo, M.K. Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents. J.Med.Chem., 63:14724-14739, 2020 Cited by PubMed: 33205981DOI: 10.1021/acs.jmedchem.0c01287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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