6XD9
Carbonmonoxy hemoglobin in complex with the antisickling agent 2-hydroxy-6-((6-(hydroxymethyl)pyridin-2-yl)methoxy)benzaldehyde (VZHE039)
Summary for 6XD9
Entry DOI | 10.2210/pdb6xd9/pdb |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total) |
Functional Keywords | hemoglobin, aromatic aldehyde, antisickling, allosteric effector, oxygen transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 65149.64 |
Authors | Pagare, P.P.,Safo, M.K.,Musayev, F.N. (deposition date: 2020-06-10, release date: 2020-12-23, Last modification date: 2023-10-18) |
Primary citation | Abdulmalik, O.,Pagare, P.P.,Huang, B.,Xu, G.G.,Ghatge, M.S.,Xu, X.,Chen, Q.,Anabaraonye, N.,Musayev, F.N.,Omar, A.M.,Venitz, J.,Zhang, Y.,Safo, M.K. VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions. Sci Rep, 10:20277-20277, 2020 Cited by PubMed: 33219275DOI: 10.1038/s41598-020-77171-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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