6WJY
HUMAN IDO1 IN COMPLEX WITH COMPOUND 4-A
Summary for 6WJY
Entry DOI | 10.2210/pdb6wjy/pdb |
Descriptor | Indoleamine 2,3-dioxygenase 1, 3-chloro-N-(3-{(2S)-1-[(4-fluorophenyl)amino]-1-oxopropan-2-yl}bicyclo[1.1.1]pentan-1-yl)benzamide (3 entities in total) |
Functional Keywords | indoleamine dioxygenase, heme, inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 89483.90 |
Authors | Lesburg, C.A.,Lammens, A.,Neumann, L. (deposition date: 2020-04-14, release date: 2020-08-26, Last modification date: 2024-04-03) |
Primary citation | Pu, Q.,Zhang, H.,Guo, L.,Cheng, M.,Doty, A.C.,Ferguson, H.,Fradera, X.,Lesburg, C.A.,McGowan, M.A.,Miller, J.R.,Geda, P.,Song, X.,Otte, K.,Sciammetta, N.,Solban, N.,Yu, W.,Sloman, D.L.,Zhou, H.,Lammens, A.,Neumann, L.,Bennett, D.J.,Pasternak, A.,Han, Y. Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors. Acs Med.Chem.Lett., 11:1548-1554, 2020 Cited by PubMed: 32832022DOI: 10.1021/acsmedchemlett.0c00195 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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