6VXG
Structure of the C-terminal Domain of RAGE and Its Inhibitor
Summary for 6VXG
Entry DOI | 10.2210/pdb6vxg/pdb |
Related | 2LMB |
NMR Information | BMRB: 30726 |
Descriptor | Advanced glycosylation end product-specific receptor, N-(4-{7-cyano-4-[(morpholin-4-yl)methyl]quinolin-2-yl}phenyl)acetamide (2 entities in total) |
Functional Keywords | inhibitor, complex, diabetes, receptor for advanced glycated end products, inflammation, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 5421.69 |
Authors | Ramirez, L.,Shekhtman, A. (deposition date: 2020-02-21, release date: 2021-02-24, Last modification date: 2024-05-15) |
Primary citation | Manigrasso, M.B.,Rabbani, P.,Egana-Gorrono, L.,Quadri, N.,Frye, L.,Zhou, B.,Reverdatto, S.,Ramirez, L.S.,Dansereau, S.,Pan, J.,Li, H.,D'Agati, V.D.,Ramasamy, R.,DeVita, R.J.,Shekhtman, A.,Schmidt, A.M. Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Sci Transl Med, 13:eabf7084-eabf7084, 2021 Cited by PubMed: 34818060DOI: 10.1126/scitranslmed.abf7084 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report