6VWG
Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Summary for 6VWG
Entry DOI | 10.2210/pdb6vwg/pdb |
EMDB information | 21415 21416 |
Descriptor | Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain, Insulin-like growth factor II, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | type 1 insulin-like growth factor receptor, insulin-like growth factor ii, ectodomain receptor, tyrosine kinase, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 226243.79 |
Authors | Xu, Y.,Kirk, N.S.,Lawrence, M.C.,Croll, T.I. (deposition date: 2020-02-19, release date: 2020-05-13, Last modification date: 2020-07-29) |
Primary citation | Xu, Y.,Kirk, N.S.,Venugopal, H.,Margetts, M.B.,Croll, T.I.,Sandow, J.J.,Webb, A.I.,Delaine, C.A.,Forbes, B.E.,Lawrence, M.C. How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28:786-798.e6, 2020 Cited by PubMed: 32459985DOI: 10.1016/j.str.2020.05.002 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.21 Å) |
Structure validation
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