6VAJ
Crystal Structure Analysis of human PIN1
Summary for 6VAJ
Entry DOI | 10.2210/pdb6vaj/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, 2-chloro-N-(2,2-dimethylpropyl)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | ppiase, covalent inhibitor, isomerase, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20512.18 |
Authors | Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2019-12-17, release date: 2020-12-30, Last modification date: 2023-10-11) |
Primary citation | Dubiella, C.,Pinch, B.J.,Koikawa, K.,Zaidman, D.,Poon, E.,Manz, T.D.,Nabet, B.,He, S.,Resnick, E.,Rogel, A.,Langer, E.M.,Daniel, C.J.,Seo, H.S.,Chen, Y.,Adelmant, G.,Sharifzadeh, S.,Ficarro, S.B.,Jamin, Y.,Martins da Costa, B.,Zimmerman, M.W.,Lian, X.,Kibe, S.,Kozono, S.,Doctor, Z.M.,Browne, C.M.,Yang, A.,Stoler-Barak, L.,Shah, R.B.,Vangos, N.E.,Geffken, E.A.,Oren, R.,Koide, E.,Sidi, S.,Shulman, Z.,Wang, C.,Marto, J.A.,Dhe-Paganon, S.,Look, T.,Zhou, X.Z.,Lu, K.P.,Sears, R.C.,Chesler, L.,Gray, N.S.,London, N. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat.Chem.Biol., 17:954-963, 2021 Cited by PubMed: 33972797DOI: 10.1038/s41589-021-00786-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
Download full validation report