6V94
Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods
Summary for 6V94
Entry DOI | 10.2210/pdb6v94/pdb |
Descriptor | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total) |
Functional Keywords | ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 95643.21 |
Authors | Phan, J.,Fesik, S.W. (deposition date: 2019-12-13, release date: 2020-08-26, Last modification date: 2023-11-15) |
Primary citation | Sarkar, D.,Olejniczak, E.T.,Phan, J.,Coker, J.A.,Sai, J.,Arnold, A.,Beesetty, Y.,Waterson, A.G.,Fesik, S.W. Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63:8325-8337, 2020 Cited by PubMed: 32673492DOI: 10.1021/acs.jmedchem.0c00511 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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