6UWU
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0516
Summary for 6UWU
Entry DOI | 10.2210/pdb6uwu/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 2-{4-[(2R)-2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]-3,5-dimethylphenyl}-5,7-dimethoxy-4H-1-benzopyran-4-one, ... (4 entities in total) |
Functional Keywords | bromodomain, inhibitor, complex, gene regulation, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15892.29 |
Authors | Leonard, P.G.,Joseph, S. (deposition date: 2019-11-05, release date: 2020-04-15, Last modification date: 2023-10-11) |
Primary citation | Liu, Z.,Chen, H.,Wang, P.,Li, Y.,Wold, E.A.,Leonard, P.G.,Joseph, S.,Brasier, A.R.,Tian, B.,Zhou, J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J.Med.Chem., 63:5242-5256, 2020 Cited by PubMed: 32255647DOI: 10.1021/acs.jmedchem.0c00035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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