6UVM
Cocrystal of BRD4(D1) with a methyl carbamate thiazepane inhibitor
Summary for 6UVM
Entry DOI | 10.2210/pdb6uvm/pdb |
Descriptor | Bromodomain-containing protein 4, 1-[(7S)-7-(thiophen-2-yl)-6,7-dihydro-1,4-thiazepin-4(5H)-yl]ethan-1-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | brd4(d1), inhibitor, gene regulation-inhibitor complex, gene regulation/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15400.80 |
Authors | Johnson, J.A.,Pomerantz, W.C.K. (deposition date: 2019-11-03, release date: 2020-01-01, Last modification date: 2023-10-11) |
Primary citation | Johnson, J.A.,Nicolaou, C.A.,Kirberger, S.E.,Pandey, A.K.,Hu, H.,Pomerantz, W.C.K. Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. Acs Med.Chem.Lett., 10:1648-1654, 2019 Cited by PubMed: 31857841DOI: 10.1021/acsmedchemlett.9b00414 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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