6UH4

B. theta Bile Salt Hydrolase with covalent inhibitor

Summary for 6UH4

Entry DOI	10.2210/pdb6uh4/pdb
Related	6UFY
Descriptor	Choloylglycine hydrolase, (5R,6R)-6-[(1S,2R,4aS,4bS,7R,8aS,10R,10aS)-7,10-dihydroxy-1,2,4b-trimethyltetradecahydrophenanthren-2-yl]-5-methylheptan-2-one (2 entities in total)
Functional Keywords	bile salt hydrolase b. theta, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bacteroides thetaiotaomicron
Total number of polymer chains	4
Total formula weight	152241.37
Authors	Seegar, T.C.M. (deposition date: 2019-09-26, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citation	Adhikari, A.A.,Seegar, T.C.M.,Ficarro, S.B.,McCurry, M.D.,Ramachandran, D.,Yao, L.,Chaudhari, S.N.,Ndousse-Fetter, S.,Banks, A.S.,Marto, J.A.,Blacklow, S.C.,Devlin, A.S. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat.Chem.Biol., 16:318-326, 2020 Cited by PubMed: 32042200 DOI: 10.1038/s41589-020-0467-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.51 Å)

Structure validation