6UCG
Retinoic acid receptor-related orphan receptor (ROR) gamma in complex with allosteric compound 28
Summary for 6UCG
Entry DOI | 10.2210/pdb6ucg/pdb |
Related | 5C4T |
Descriptor | Nuclear receptor ROR-gamma, (3S,4R)-1-[1-(2-chloro-6-cyclopropylbenzene-1-carbonyl)-4-fluoro-1H-indazol-3-yl]-3-hydroxypiperidine-4-carboxylic acid (3 entities in total) |
Functional Keywords | ror gamma t, allosteric, nuclear receptor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 28642.55 |
Authors | Palte, R.L.,Parthasarathy, G. (deposition date: 2019-09-16, release date: 2020-03-04, Last modification date: 2024-03-13) |
Primary citation | Zhang, H.,Lapointe, B.T.,Anthony, N.,Azevedo, R.,Cals, J.,Correll, C.C.,Daniels, M.,Deshmukh, S.,van Eenenaam, H.,Ferguson, H.,Hegde, L.G.,Karstens, W.J.,Maclean, J.,Miller, J.R.,Moy, L.Y.,Simov, V.,Nagpal, S.,Oubrie, A.,Palte, R.L.,Parthasarathy, G.,Sciammetta, N.,van der Stelt, M.,Woodhouse, J.D.,Trotter, B.W.,Barr, K. Discovery ofN-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR gamma t Allosteric Inhibitors for Autoimmune Diseases. Acs Med.Chem.Lett., 11:114-119, 2020 Cited by PubMed: 32071676DOI: 10.1021/acsmedchemlett.9b00431 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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