6TW0
Human CD73 (ecto 5'-nucleotidase) in complex with PSB12690 (an AOPCP derivative, compound 10 in publication) in the closed state
Summary for 6TW0
Entry DOI | 10.2210/pdb6tw0/pdb |
Descriptor | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid, ... (4 entities in total) |
Functional Keywords | nucleotide analog, en, 5nt, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 59832.45 |
Authors | Pippel, J.,Strater, N. (deposition date: 2020-01-10, release date: 2020-02-19, Last modification date: 2024-01-24) |
Primary citation | Bhattarai, S.,Pippel, J.,Scaletti, E.,Idris, R.,Freundlieb, M.,Rolshoven, G.,Renn, C.,Lee, S.Y.,Abdelrahman, A.,Zimmermann, H.,El-Tayeb, A.,Muller, C.E.,Strater, N. 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63:2941-2957, 2020 Cited by PubMed: 32045236DOI: 10.1021/acs.jmedchem.9b01611 PDB entries with the same primary citation |
Experimental method |
Structure validation
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