6TTI
PKM2 in complex with Compound 6
Summary for 6TTI
Entry DOI | 10.2210/pdb6tti/pdb |
EMDB information | 10575 10576 10577 |
Descriptor | Pyruvate kinase PKM, ~{N}-[3-(trifluoromethyl)-1,2-oxazol-5-yl]ethanamide, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (5 entities in total) |
Functional Keywords | pkm2, fbdd, cytosolic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 241776.72 |
Authors | Saur, M.,Hartshorn, M.J.,Dong, J.,Reeks, J.,Bunkoczi, G.,Jhoti, H.,Williams, P.A. (deposition date: 2019-12-27, release date: 2020-01-15, Last modification date: 2024-05-22) |
Primary citation | Saur, M.,Hartshorn, M.J.,Dong, J.,Reeks, J.,Bunkoczi, G.,Jhoti, H.,Williams, P.A. Fragment-based drug discovery using cryo-EM. Drug Discov Today, 25:485-490, 2020 Cited by PubMed: 31877353DOI: 10.1016/j.drudis.2019.12.006 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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