6TON
Crystal structure of human BCL6 BTB domain in complex with compound 25b
Summary for 6TON
Entry DOI | 10.2210/pdb6ton/pdb |
Descriptor | B-cell lymphoma 6 protein, ALA-TRP-VAL-ILE-PRO-ALA, 5-[[5-chloranyl-2-(2,2,6,6-tetramethylmorpholin-4-yl)pyrimidin-4-yl]amino]-1-methyl-3-(3-methyl-3-oxidanyl-butyl)benzimidazol-2-one, ... (5 entities in total) |
Functional Keywords | cancer, lymphoma, inhibitor, degrader, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 15819.87 |
Authors | Rodrigues, M.J.,Le Bihan, Y.-V.,van Montfort, R.L.M. (deposition date: 2019-12-11, release date: 2020-04-22, Last modification date: 2024-01-24) |
Primary citation | Bellenie, B.R.,Cheung, K.J.,Varela, A.,Pierrat, O.A.,Collie, G.W.,Box, G.M.,Bright, M.D.,Gowan, S.,Hayes, A.,Rodrigues, M.J.,Shetty, K.N.,Carter, M.,Davis, O.A.,Henley, A.T.,Innocenti, P.,Johnson, L.D.,Liu, M.,de Klerk, S.,Le Bihan, Y.V.,Lloyd, M.G.,McAndrew, P.C.,Shehu, E.,Talbot, R.,Woodward, H.L.,Burke, R.,Kirkin, V.,van Montfort, R.L.M.,Raynaud, F.I.,Rossanese, O.W.,Hoelder, S. AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J.Med.Chem., 63:4047-4068, 2020 Cited by PubMed: 32275432DOI: 10.1021/acs.jmedchem.9b02076 PDB entries with the same primary citation |
Experimental method |
Structure validation
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