6TI9
Human transthyretin (TTR) complexed with (E)-3-(((3,5-dibromo-2-hydroxybenzylidene)amino)oxy)propanoic acid.
Summary for 6TI9
| Entry DOI | 10.2210/pdb6ti9/pdb |
| Descriptor | Transthyretin, 3-[(~{E})-[3,5-bis(bromanyl)-2-oxidanyl-phenyl]methylideneamino]oxypropanoic acid, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | transthyretin, ttr, inhibitor, complex, protein transport |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28647.09 |
| Authors | Ciccone, L.,Nencetti, S.,Orlandini, E.,Rossello, A.,Legrand, P.,Shepard, W. (deposition date: 2019-11-22, release date: 2020-10-21, Last modification date: 2024-01-24) |
| Primary citation | Ciccone, L.,Nencetti, S.,Tonali, N.,Fruchart-Gaillard, C.,Shepard, W.,Nuti, E.,Camodeca, C.,Rossello, A.,Orlandini, E. Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis. Bioorg.Med.Chem., 28:115673-115673, 2020 Cited by PubMed: 32828431DOI: 10.1016/j.bmc.2020.115673 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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