6THC
Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and (4-hydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone
Summary for 6THC
Entry DOI | 10.2210/pdb6thc/pdb |
Descriptor | Coenzyme A biosynthesis bifunctional protein CoaBC, CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | coabc, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoylcysteine decarboxylase, phosphopantothenoylcysteine synthetase, ligase |
Biological source | Mycolicibacterium smegmatis |
Total number of polymer chains | 4 |
Total formula weight | 102843.32 |
Authors | Mendes, V.,Blaszczyk, M.,Bryant, O.,Cory-Wright, J.,Blundell, T.L. (deposition date: 2019-11-19, release date: 2020-11-25, Last modification date: 2024-01-24) |
Primary citation | Mendes, V.,Green, S.R.,Evans, J.C.,Hess, J.,Blaszczyk, M.,Spry, C.,Bryant, O.,Cory-Wright, J.,Chan, D.S.,Torres, P.H.M.,Wang, Z.,Nahiyaan, N.,O'Neill, S.,Damerow, S.,Post, J.,Bayliss, T.,Lynch, S.L.,Coyne, A.G.,Ray, P.C.,Abell, C.,Rhee, K.Y.,Boshoff, H.I.M.,Barry, C.E.,Mizrahi, V.,Wyatt, P.G.,Blundell, T.L. Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site. Nat Commun, 12:143-143, 2021 Cited by PubMed: 33420031DOI: 10.1038/s41467-020-20224-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.033 Å) |
Structure validation
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