6T7K

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with NCP-26 and L-Proline

Summary for 6T7K

• Entry DOI: 10.2210/pdb6t7k/pdb
• Descriptor: Proline--tRNA ligase, PROLINE, ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-3-(piperidin-1-ylcarbonylamino)pyrazine-2-carboxamide, ... (5 entities in total)
• Functional Keywords: trna, proline, aminoacyl-trna synthetase, ligase, protein biosynthesis, atp binding
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 1
• Total formula weight: 60310.91

Authors

Johansson, C.,Wang, J.,Tye, M.,Payne, N.C.,Mazitschek, R.,Thompson, A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U.C.T. (deposition date: 2019-10-22, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Johansson, C.,Wang, J.,Tye, M.,Payne, N.C.,Mazitschek, R.,Thompson, A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U.C.T.; Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with NCP-26 and L-Proline; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.79 Å)