6T0L

Crystal structure of CYP124 in complex with inhibitor compound 5'

Summary for 6T0L

• Entry DOI: 10.2210/pdb6t0l/pdb
• Descriptor: CYP124 in complex with inhibitor compound 5', PROTOPORPHYRIN IX CONTAINING FE, ~{N}-[[[2-methyl-4-(3-methylbutyl)phenyl]amino]methyl]hydroxylamine, ... (8 entities in total)
• Functional Keywords: cytochrome, p450, cyp, cyp124, 124, oxidoreductase, inhibition, inhibitor, drug, antituberculosis, tuberculosis, mycobacterium tuberculosis, compound, 5'
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 1
• Total formula weight: 50329.89

Authors

Bukhdruker, S.,Marin, E.,Varaksa, T.,Gilep, A.,Strushkevich, N.,Borshchevskiy, V. (deposition date: 2019-10-03, release date: 2020-10-14, Last modification date: 2024-01-24)

• Primary citation: Varaksa, T.,Bukhdruker, S.,Grabovec, I.,Marin, E.,Kavaleuski, A.,Gusach, A.,Kovalev, K.,Maslov, I.,Luginina, A.,Zabelskii, D.,Astashkin, R.,Shevtsov, M.,Smolskaya, S.,Kavaleuskaya, A.,Shabunya, P.,Baranovsky, A.,Dolgopalets, V.,Charnou, Y.,Savachka, A.,Litvinovskaya, R.,Hurski, A.,Shevchenko, E.,Rogachev, A.,Mishin, A.,Gordeliy, V.,Gabrielian, A.,Hurt, D.E.,Nikonenko, B.,Majorov, K.,Apt, A.,Rosenthal, A.,Gilep, A.,Borshchevskiy, V.,Strushkevich, N.; Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.; J.Mol.Biol., 433:166763-166763, 2021; PubMed: 33359098; DOI: 10.1016/j.jmb.2020.166763

Experimental method

X-RAY DIFFRACTION (1.8 Å)