6SU0

Crystal structure of dimethylated RSLex in complex with cucurbit[7]uril

Summary for 6SU0

Entry DOI	10.2210/pdb6su0/pdb
Descriptor	Fucose-binding lectin protein, SODIUM ION, cucurbit[7]uril, ... (5 entities in total)
Functional Keywords	cucurbituril, molecular glue, crystal engineering, sugar binding protein
Biological source	Ralstonia solanacearum
Total number of polymer chains	12
Total formula weight	134405.46
Authors	Guagnini, F.,Engilberge, S.,Crowley, P.B. (deposition date: 2019-09-12, release date: 2020-02-19, Last modification date: 2024-01-24)
Primary citation	Guagnini, F.,Engilberge, S.,Ramberg, K.O.,Perez, J.,Crowley, P.B. Engineered assembly of a protein-cucurbituril biohybrid. Chem.Commun.(Camb.), 56:360-363, 2020 Cited by PubMed Abstract: A crystalline biohybrid with a 4 : 1 protein : cucurbituril mass ratio is presented. This result was achieved by engineering additional cucurbit[7]uril (Q7) binding sites into a β-propeller protein. In contrast to the parent protein, Q7-controlled assembly of the engineered variant occurred in solution, as evidenced by NMR and SAXS measurements. PubMed: 31825399 DOI: 10.1039/c9cc07198a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation