6SNW
Structure of Coxsackievirus A10 complexed with its receptor KREMEN1
Summary for 6SNW
| Entry DOI | 10.2210/pdb6snw/pdb |
| Related | 6SMG 6SNB |
| EMDB information | 10263 |
| Descriptor | Capsid protein VP1, Coxsackievirus VP2, Capsid protein VP3, ... (7 entities in total) |
| Functional Keywords | cv-a10, kremen1, virus-receptor complex, hand, foot and mouth disease, virus, picornavirus uncoating intermediate |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 5 |
| Total formula weight | 137133.34 |
| Authors | Zhao, Y.,Zhou, D.,Ni, T.,Karia, D.,Kotecha, A.,Wang, X.,Rao, Z.,Jones, E.Y.,Fry, E.E.,Ren, J.,Stuart, D.I. (deposition date: 2019-08-27, release date: 2020-01-15, Last modification date: 2024-11-06) |
| Primary citation | Zhao, Y.,Zhou, D.,Ni, T.,Karia, D.,Kotecha, A.,Wang, X.,Rao, Z.,Jones, E.Y.,Fry, E.E.,Ren, J.,Stuart, D.I. Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10. Nat Commun, 11:38-38, 2020 Cited by PubMed Abstract: Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently available. KREMEN1 (KRM1) is the entry receptor for the largest receptor-group of hand-foot-and-mouth disease causing viruses, which includes CV-A10. We report here structures of CV-A10 mature virus alone and in complex with KRM1 as well as of the CV-A10 A-particle. The receptor spans the viral canyon with a large footprint on the virus surface. The footprint has some overlap with that seen for the neonatal Fc receptor complexed with enterovirus E6 but is larger and distinct from that of another enterovirus receptor SCARB2. Reduced occupancy of a particle-stabilising pocket factor in the complexed virus and the presence of both unbound and expanded virus particles suggests receptor binding initiates a cascade of conformational changes that produces expanded particles primed for viral uncoating. PubMed: 31911601DOI: 10.1038/s41467-019-13936-2 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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