6SJU

Human kallikrein 7 with aromatic coumarinic ester compound 3 covalently bound to H57

Summary for 6SJU

• Entry DOI: 10.2210/pdb6sju/pdb
• Descriptor: Kallikrein-7, TRIETHYLENE GLYCOL, SULFATE ION, ... (6 entities in total)
• Functional Keywords: serine protease, covalent inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 209121.97

Authors

Hanke, S.,Straeter, N. (deposition date: 2019-08-13, release date: 2020-05-20, Last modification date: 2024-01-24)

• Primary citation: Hanke, S.,Tindall, C.A.,Pippel, J.,Ulbricht, D.,Pirotte, B.,Reboud-Ravaux, M.,Heiker, J.T.,Strater, N.; Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7.; J.Med.Chem., 63:5723-5733, 2020; PubMed: 32374603; DOI: 10.1021/acs.jmedchem.9b01806

Experimental method

X-RAY DIFFRACTION (1.97 Å)