6SI3
p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301
Summary for 6SI3
Entry DOI | 10.2210/pdb6si3/pdb |
Descriptor | Cellular tumor antigen p53, ZINC ION, 1-[7-bromanyl-9-[2,2,2-tris(fluoranyl)ethyl]carbazol-3-yl]-~{N}-methyl-methanamine, ... (6 entities in total) |
Functional Keywords | p53, transcription factor, tumor suppressor, cancer therapy, oncogenic mutant, protein misfolding, dna-binding domain, druggable surface crevice, small-molecule stabilizer, mutant p53 rescue, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 50181.00 |
Authors | Joerger, A.C.,Bauer, M.R.,Structural Genomics Consortium (SGC) (deposition date: 2019-08-08, release date: 2020-02-19, Last modification date: 2024-01-24) |
Primary citation | Bauer, M.R.,Kramer, A.,Settanni, G.,Jones, R.N.,Ni, X.,Khan Tareque, R.,Fersht, A.R.,Spencer, J.,Joerger, A.C. Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15:657-668, 2020 Cited by PubMed: 31990523DOI: 10.1021/acschembio.9b00748 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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