6SBT
Structure of GluK1 ligand-binding domain (S1S2) in complex with N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl benzamide at 2.3 A resolution
Summary for 6SBT
Entry DOI | 10.2210/pdb6sbt/pdb |
Descriptor | Glutamate receptor ionotropic, kainate 1, SULFATE ION, ~{N}-[7-imidazol-1-yl-2,3-bis(oxidanylidene)-6-(trifluoromethyl)-4~{H}-quinoxalin-1-yl]benzamide, ... (6 entities in total) |
Functional Keywords | kainate receptor ligand-binding domain, gluk1-s1s2, antagonist, membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 1 |
Total formula weight | 29971.00 |
Authors | Moellerud, S.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2019-07-22, release date: 2019-10-30, Last modification date: 2024-01-24) |
Primary citation | Mollerud, S.,Hansen, R.B.,Pallesen, J.,Temperini, P.,Pasini, D.,Bornholt, J.,Nielsen, B.,Mamedova, E.,Chalupnik, P.,Paternain, A.V.,Lerma, J.,Diaz-delCastillo, M.,Andreasen, J.T.,Frydenvang, K.,Kastrup, J.S.,Johansen, T.N.,Pickering, D.S. N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology. Acs Chem Neurosci, 10:4685-4695, 2019 Cited by PubMed: 31622082DOI: 10.1021/acschemneuro.9b00479 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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