6SAM

Structure of human butyrylcholinesterase in complex with 1-(2,3-dihydro-1H-inden2-yl)piperidin-3-yl N-phenyl carbamate

Summary for 6SAM

Entry DOI	10.2210/pdb6sam/pdb
Descriptor	Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	butyrylcholinesterase, inhibitor, complex, carbamate, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	63026.79
Authors	Brazzolotto, X.,Kosak, U.,Strasek, N.,Knez, D.,Gobec, S.,Nachon, F. (deposition date: 2019-07-17, release date: 2020-04-29, Last modification date: 2024-01-24)
Primary citation	Kosak, U.,Strasek, N.,Knez, D.,Jukic, M.,Zakelj, S.,Zahirovic, A.,Pislar, A.,Brazzolotto, X.,Nachon, F.,Kos, J.,Gobec, S. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur.J.Med.Chem., 197:112282-112282, 2020 Cited by PubMed: 32380361 DOI: 10.1016/j.ejmech.2020.112282 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation