6S03
Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379
Summary for 6S03
Entry DOI | 10.2210/pdb6s03/pdb |
Related | 6RZX |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-[[4-[5,5-dimethyl-2-(6-methylpyridin-2-yl)-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-yl]amino]benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitor, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29726.85 |
Authors | Kugler, M.,Brynda, J.,Rezacova, P. (deposition date: 2019-06-13, release date: 2020-06-03, Last modification date: 2024-01-24) |
Primary citation | Tykvart, J.,Navratil, V.,Kugler, M.,Sacha, P.,Schimer, J.,Hlavackova, A.,Tenora, L.,Zemanova, J.,Dejmek, M.,Kral, V.,Potacek, M.,Majer, P.,Jahn, U.,Brynda, J.,Rezacova, P.,Konvalinka, J. Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25:1026-1037, 2020 Cited by PubMed: 32452709DOI: 10.1177/2472555220918836 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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