6RQ4

Inhibitor of ERK2

Summary for 6RQ4

Entry DOI	10.2210/pdb6rq4/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, 6,6-dimethyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5-(2-morpholin-4-ylethyl)thieno[2,3-c]pyrrol-4-one, ... (4 entities in total)
Functional Keywords	protein kinase atp-binding site serine/threonine kinase, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43101.54
Authors	O'Reilly, M. (deposition date: 2019-05-15, release date: 2019-12-04, Last modification date: 2020-02-19)
Primary citation	Kidger, A.M.,Munck, J.M.,Saini, H.K.,Balmanno, K.,Minihane, E.,Courtin, A.,Graham, B.,O'Reilly, M.,Odle, R.,Cook, S.J. Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2. Mol.Cancer Ther., 19:525-539, 2020 Cited by PubMed: 31748345 DOI: 10.1158/1535-7163.MCT-19-0505 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation