6RMF

Crystal structure of NDM-1 with VNRX-5133

Summary for 6RMF

• Entry DOI: 10.2210/pdb6rmf/pdb
• Descriptor: Metallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ... (6 entities in total)
• Functional Keywords: metallo-beta-lactamase, antibiotic resistance, inhibitor, antimicrobial protein
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 53284.48

Authors

Hinchliffe, P.,Spencer, J.,Brem, J.,Schofield, C.J. (deposition date: 2019-05-06, release date: 2019-09-11, Last modification date: 2024-01-24)

• Primary citation: Krajnc, A.,Brem, J.,Hinchliffe, P.,Calvopina, K.,Panduwawala, T.D.,Lang, P.A.,Kamps, J.J.A.G.,Tyrrell, J.M.,Widlake, E.,Saward, B.G.,Walsh, T.R.,Spencer, J.,Schofield, C.J.; Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-beta-Lactamases.; J.Med.Chem., 62:8544-8556, 2019; PubMed: 31454231; DOI: 10.1021/acs.jmedchem.9b00911

Experimental method

X-RAY DIFFRACTION (1.51 Å)