6RMF
Crystal structure of NDM-1 with VNRX-5133
Summary for 6RMF
Entry DOI | 10.2210/pdb6rmf/pdb |
Descriptor | Metallo-beta-lactamase type 2, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | metallo-beta-lactamase, antibiotic resistance, inhibitor, antimicrobial protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 53284.48 |
Authors | Hinchliffe, P.,Spencer, J.,Brem, J.,Schofield, C.J. (deposition date: 2019-05-06, release date: 2019-09-11, Last modification date: 2024-01-24) |
Primary citation | Krajnc, A.,Brem, J.,Hinchliffe, P.,Calvopina, K.,Panduwawala, T.D.,Lang, P.A.,Kamps, J.J.A.G.,Tyrrell, J.M.,Widlake, E.,Saward, B.G.,Walsh, T.R.,Spencer, J.,Schofield, C.J. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-beta-Lactamases. J.Med.Chem., 62:8544-8556, 2019 Cited by PubMed: 31454231DOI: 10.1021/acs.jmedchem.9b00911 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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