6R9U
Human Cyclophilin D in complex with fragment
Summary for 6R9U
Entry DOI | 10.2210/pdb6r9u/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase F, mitochondrial, 14-ethyl-4,6-dioxa-10,14-diazatricyclo[7.6.0.0^{3,7}]pentadeca-1(9),2,7-trien-13-one, SULFATE ION, ... (6 entities in total) |
Functional Keywords | cyclophilin, beta barrel, prolyl cis/trans isomerase, mitoc, isomerase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 18641.21 |
Authors | Graedler, U. (deposition date: 2019-04-04, release date: 2019-11-27, Last modification date: 2024-01-24) |
Primary citation | Gradler, U.,Schwarz, D.,Blaesse, M.,Leuthner, B.,Johnson, T.L.,Bernard, F.,Jiang, X.,Marx, A.,Gilardone, M.,Lemoine, H.,Roche, D.,Jorand-Lebrun, C. Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies. Bioorg.Med.Chem.Lett., 29:126717-126717, 2019 Cited by PubMed: 31635932DOI: 10.1016/j.bmcl.2019.126717 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
Download full validation report