6R7J
Ligand complex of RORg LBD
Summary for 6R7J
Entry DOI | 10.2210/pdb6r7j/pdb |
Descriptor | Nuclear receptor ROR-gamma, SRC2 peptide, (2~{R})-2-acetamido-2-(4-ethylsulfonylphenyl)-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]ethanamide, ... (6 entities in total) |
Functional Keywords | rar-related orphan receptor-g (rorg), transcription, rorg ligand, structure-based design |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 35375.52 |
Authors | Xue, Y.,Aagaard, A.,Narjes, F. (deposition date: 2019-03-29, release date: 2019-07-03, Last modification date: 2024-05-15) |
Primary citation | von Berg, S.,Xue, Y.,Collins, M.,Llinas, A.,Olsson, R.I.,Halvarsson, T.,Lindskog, M.,Malmberg, J.,Jirholt, J.,Krutrok, N.,Ramnegard, M.,Brannstrom, M.,Lundqvist, A.,Lepisto, M.,Aagaard, A.,McPheat, J.,Hansson, E.L.,Chen, R.,Xiong, Y.,Hansson, T.G.,Narjes, F. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. Acs Med.Chem.Lett., 10:972-977, 2019 Cited by PubMed: 31223457DOI: 10.1021/acsmedchemlett.9b00158 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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