6R67

Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue

Summary for 6R67

Entry DOI	10.2210/pdb6r67/pdb
Descriptor	Transthyretin, (2~{R})-2-[4-(3,5-dimethylphenyl)-3-fluoranyl-phenyl]propanoic acid (3 entities in total)
Functional Keywords	amyloidosis, tetramer, binding protein, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	32354.60
Authors	Loconte, V.,Menozzi, I.,Ferrari, A.,Berni, R.,Zanotti, G. (deposition date: 2019-03-26, release date: 2019-09-11, Last modification date: 2019-11-06)
Primary citation	Loconte, V.,Menozzi, I.,Ferrari, A.,Folli, C.,Imbimbo, B.P.,Zanotti, G.,Berni, R. Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208:165-173, 2019 Cited by PubMed: 31473362 DOI: 10.1016/j.jsb.2019.08.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation