6R4A
Aurora-A in complex with shape-diverse fragment 55
Summary for 6R4A
Entry DOI | 10.2210/pdb6r4a/pdb |
Descriptor | Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... (7 entities in total) |
Functional Keywords | ser/thr kinase allosteric site, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34045.78 |
Authors | Bayliss, R.,McIntyre, P.J. (deposition date: 2019-03-22, release date: 2019-05-08, Last modification date: 2024-01-24) |
Primary citation | Zhang, R.,McIntyre, P.J.,Collins, P.M.,Foley, D.J.,Arter, C.,von Delft, F.,Bayliss, R.,Warriner, S.,Nelson, A. Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase. Chemistry, 25:6831-6839, 2019 Cited by PubMed: 31026091DOI: 10.1002/chem.201900815 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.937 Å) |
Structure validation
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