6QLU

Galectin-3C in complex with fluoroaryltriazole monothiogalactoside derivative-8

Summary for 6QLU

• Entry DOI: 10.2210/pdb6qlu/pdb
• Descriptor: Galectin-3, (2~{R},3~{R},4~{S},5~{R},6~{S})-4-[4-(4-fluoranyl-3-methyl-phenyl)-1,2,3-triazol-1-yl]-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-oxane-3,5-diol, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: lectin, carbohydrate-binding protein, galactose-specific lectin 3, galactoside-binding protein, galbp, ige-6 binding protein, l-31, laminin-binding protein, lectin l-29, mac-2, sugar binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16182.01

Authors

Kumar, R.,Peterson, K.,Nilsson, U.J.,Logan, D.T. (deposition date: 2019-02-01, release date: 2019-07-10, Last modification date: 2024-01-24)

• Primary citation: Kumar, R.,Ignjatovic, M.M.,Peterson, K.,Olsson, M.,Leffler, H.,Ryde, U.,Nilsson, U.J.,Logan, D.T.; Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions.; Chemmedchem, 14:1528-1536, 2019; PubMed: 31246331; DOI: 10.1002/cmdc.201900293

Experimental method

X-RAY DIFFRACTION (1.1 Å)