6QGD
Structure of human Mcl-1 in complex with thienopyrimidine inhibitor
Summary for 6QGD
Entry DOI | 10.2210/pdb6qgd/pdb |
Related | 6qfi 6qfm 6qfq |
Related PRD ID | PRD_900001 |
Descriptor | Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 2-[(6-ethyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)amino]-3-oxidanyl-propanoic acid, ... (5 entities in total) |
Functional Keywords | apoptosis, mcl1, mbp, small molecule inhibitor |
Biological source | Escherichia coli O157:H7 More |
Total number of polymer chains | 1 |
Total formula weight | 57934.55 |
Authors | Dokurno, P.,Murray, J.,Davidson, J.,Chen, I.,Davis, B.,Graham, C.J.,Harris, R.,Jordan, A.M.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E. (deposition date: 2019-01-11, release date: 2019-06-12, Last modification date: 2024-01-24) |
Primary citation | Murray, J.B.,Davidson, J.,Chen, I.,Davis, B.,Dokurno, P.,Graham, C.J.,Harris, R.,Jordan, A.,Matassova, N.,Pedder, C.,Ray, S.,Roughley, S.D.,Smith, J.,Walmsley, C.,Wang, Y.,Whitehead, N.,Williamson, D.S.,Casara, P.,Le Diguarher, T.,Hickman, J.,Stark, J.,Kotschy, A.,Geneste, O.,Hubbard, R.E. Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4:8892-8906, 2019 Cited by PubMed: 31459977DOI: 10.1021/acsomega.9b00611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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