6QDH
Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000906
Summary for 6QDH
Entry DOI | 10.2210/pdb6qdh/pdb |
Related | 4CGO |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 4-[ethyl(methyl)amino]-2-[methyl-(1-methylpiperidin-4-yl)amino]-~{N}-(1,3,5-trimethylpyrazol-4-yl)quinazoline-6-sulfonamide, ... (7 entities in total) |
Functional Keywords | transferase, myristoylation, quinazoline, leishmania |
Biological source | Leishmania major |
Total number of polymer chains | 1 |
Total formula weight | 50590.80 |
Authors | Brannigan, J.A. (deposition date: 2019-01-01, release date: 2020-05-06, Last modification date: 2024-01-24) |
Primary citation | Bell, A.S.,Yu, Z.,Hutton, J.A.,Wright, M.H.,Brannigan, J.A.,Paape, D.,Roberts, S.M.,Sutherell, C.L.,Ritzefeld, M.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63:7740-7765, 2020 Cited by PubMed: 32575985DOI: 10.1021/acs.jmedchem.0c00570 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
Download full validation report