6QD9
Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000065
Summary for 6QD9
Entry DOI | 10.2210/pdb6qd9/pdb |
Related | 4CGO |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 3-[[2-[3-(dimethylamino)propyl-methyl-amino]thieno[3,2-d]pyrimidin-4-yl]-methyl-amino]propanenitrile, ... (5 entities in total) |
Functional Keywords | transferase, myristoylation, benzothiophene, leishmania |
Biological source | Leishmania major |
Total number of polymer chains | 1 |
Total formula weight | 49905.90 |
Authors | Brannigan, J.A. (deposition date: 2019-01-01, release date: 2020-05-06, Last modification date: 2024-01-24) |
Primary citation | Bell, A.S.,Yu, Z.,Hutton, J.A.,Wright, M.H.,Brannigan, J.A.,Paape, D.,Roberts, S.M.,Sutherell, C.L.,Ritzefeld, M.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63:7740-7765, 2020 Cited by PubMed: 32575985DOI: 10.1021/acs.jmedchem.0c00570 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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