6PZU
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with AP-1-62-A
Summary for 6PZU
Entry DOI | 10.2210/pdb6pzu/pdb |
Descriptor | Hdac6 protein, ZINC ION, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | histone deacetylase, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 80706.25 |
Authors | Osko, J.D.,Christianson, D.W. (deposition date: 2019-08-01, release date: 2020-02-05, Last modification date: 2023-10-11) |
Primary citation | Osko, J.D.,Porter, N.J.,Narayana Reddy, P.A.,Xiao, Y.C.,Rokka, J.,Jung, M.,Hooker, J.M.,Salvino, J.M.,Christianson, D.W. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. J.Med.Chem., 63:295-308, 2020 Cited by PubMed: 31793776DOI: 10.1021/acs.jmedchem.9b01540 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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