6PPY

Crystal structure of NeuNAc oxime complexed with NeuB, an N-acetylneuraminate synthase from Neisseria meningitidis

Summary for 6PPY

Entry DOI	10.2210/pdb6ppy/pdb
Descriptor	N-acetylneuraminate synthase, (2E,4S,5R,6R,7S,8R)-5-(acetylamino)-4,6,7,8,9-pentahydroxy-2-(hydroxyimino)nonanoic acid (non-preferred name) (3 entities in total)
Functional Keywords	neub, sialic acid synthase, inhibitor complex, n-acetyl-neuraminate synthase, neunac oxime, transferase, biosynthetic protein
Biological source	Neisseria meningitidis serogroup B
Total number of polymer chains	1
Total formula weight	38720.02
Authors	Rosanally, A.Z.,Junop, M.J.,Berti, P.J. (deposition date: 2019-07-08, release date: 2019-10-02, Last modification date: 2023-10-11)
Primary citation	Popovic, V.,Morrison, E.,Rosanally, A.Z.,Balachandran, N.,Senson, A.W.,Szabla, R.,Junop, M.S.,Berti, P.J. NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB. Biochemistry, 58:4236-4245, 2019 Cited by PubMed: 31549502 DOI: 10.1021/acs.biochem.9b00654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation