6PDA
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 74
Summary for 6PDA
Entry DOI | 10.2210/pdb6pda/pdb |
Descriptor | Histone acetyltransferase KAT8, ZINC ION, SODIUM ION, ... (7 entities in total) |
Functional Keywords | inhibitor, complex, myst, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32695.86 |
Authors | Hermans, S.J.,Parker, M.W.,Thomas, T.,Baell, J.B. (deposition date: 2019-06-18, release date: 2020-04-01, Last modification date: 2023-11-15) |
Primary citation | Priebbenow, D.L.,Leaver, D.J.,Nguyen, N.,Cleary, B.,Lagiakos, H.R.,Sanchez, J.,Xue, L.,Huang, F.,Sun, Y.,Mujumdar, P.,Mudududdla, R.,Varghese, S.,Teguh, S.,Charman, S.A.,White, K.L.,Shackleford, D.M.,Katneni, K.,Cuellar, M.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Street, I.P.,Monahan, B.J.,Jarman, K.E.,Jousset Sabroux, H.,Falk, H.,Chung, M.C.,Hermans, S.J.,Downer, N.L.,Parker, M.W.,Voss, A.K.,Thomas, T.,Baell, J.B. Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63:4655-4684, 2020 Cited by PubMed: 32118427DOI: 10.1021/acs.jmedchem.9b02071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.448 Å) |
Structure validation
Download full validation report