6P8Z
Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor
Summary for 6P8Z
Entry DOI | 10.2210/pdb6p8z/pdb |
Related | 6P8W 6P8X 6P8Y |
Descriptor | GTPase KRas, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | inhibitor, gtpase, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 44250.11 |
Authors | Mohr, C. (deposition date: 2019-06-08, release date: 2019-08-28, Last modification date: 2019-10-02) |
Primary citation | Shin, Y.,Jeong, J.W.,Wurz, R.P.,Achanta, P.,Arvedson, T.,Bartberger, M.D.,Campuzano, I.D.G.,Fucini, R.,Hansen, S.K.,Ingersoll, J.,Iwig, J.S.,Lipford, J.R.,Ma, V.,Kopecky, D.J.,McCarter, J.,San Miguel, T.,Mohr, C.,Sabet, S.,Saiki, A.Y.,Sawayama, A.,Sethofer, S.,Tegley, C.M.,Volak, L.P.,Yang, K.,Lanman, B.A.,Erlanson, D.A.,Cee, V.J. Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10:1302-1308, 2019 Cited by PubMed: 31531201DOI: 10.1021/acsmedchemlett.9b00258 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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