6ORU

Crystal structure of Bira from S. aureus in complex with a acylsulfamide analogue of biotinyl-5'-AMP

Summary for 6ORU

• Entry DOI: 10.2210/pdb6oru/pdb
• Descriptor: Bifunctional ligase/repressor BirA, N-{[4-(6-amino-9H-purin-9-yl)butyl]sulfamoyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide (3 entities in total)
• Functional Keywords: biotin'-5'-analogue inhibitor, ligase-inhibitor complex, ligase/inhibitor
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 38526.46

Authors

Wilce, M.C.J.,Cini, D. (deposition date: 2019-05-01, release date: 2020-07-01, Last modification date: 2023-10-11)

• Primary citation: Lee, K.J.,Abell, A.D.; Enhancing the stability of the sulfonamide linker of BPL inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.392 Å)