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6OQB

Co-crystal structure of Mcl1 with inhibitor 10

Summary for 6OQB
Entry DOI10.2210/pdb6oqb/pdb
Related6O6F 6O6G
DescriptorInduced myeloid leukemia cell differentiation protein Mcl-1, (4S,7aR,9aR,10S,11E,15R)-6'-chloro-15-ethyl-10-hydroxy-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione (3 entities in total)
Functional Keywordsinhibitor, apoptosis, protein-protein interaction, apoptosis-inhibitor complex, apoptosis/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight18521.52
Authors
Huang, X. (deposition date: 2019-04-26, release date: 2019-05-15, Last modification date: 2024-03-13)
Primary citationCaenepeel, S.,Brown, S.P.,Belmontes, B.,Moody, G.,Keegan, K.S.,Chui, D.,Whittington, D.A.,Huang, X.,Poppe, L.,Cheng, A.C.,Cardozo, M.,Houze, J.,Li, Y.,Lucas, B.,Paras, N.A.,Wang, X.,Taygerly, J.P.,Vimolratana, M.,Zancanella, M.,Zhu, L.,Cajulis, E.,Osgood, T.,Sun, J.,Damon, L.,Egan, R.K.,Greninger, P.,McClanaghan, J.D.,Gong, J.,Moujalled, D.,Pomilio, G.,Beltran, P.,Benes, C.H.,Roberts, A.W.,Huang, D.C.,Wei, A.,Canon, J.,Coxon, A.,Hughes, P.E.
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8:1582-1597, 2018
Cited by
PubMed: 30254093
DOI: 10.1158/2159-8290.CD-18-0387
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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