6NTG

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234 in Complex with Reactivator, HI-6

Summary for 6NTG

• Entry DOI: 10.2210/pdb6ntg/pdb
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM, ... (6 entities in total)
• Functional Keywords: hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 122037.30

Authors

Bester, S.M.,Guelta, M.A.,Height, J.J.,Pegan, S.D. (deposition date: 2019-01-29, release date: 2020-07-01, Last modification date: 2023-10-11)

• Primary citation: Height, J.J.,Bester, S.M.,Guelta, M.A.,Bae, S.Y.,Cheung, J.,Pegan, S.D.; Insights into inhibition of human acetylcholinesterase by Novichok, A-series Nerve Agents; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.652 Å)