6N33
Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622
Summary for 6N33
Entry DOI | 10.2210/pdb6n33/pdb |
Descriptor | Macrophage colony-stimulating factor 1 receptor, 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine (3 entities in total) |
Functional Keywords | csf-1-r, fms proto-oncogene, c-fms, cd115 antigen, kinase, atp-binding, plx5622, transferase-transferase inhibitor complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39035.58 |
Authors | Zhang, Y. (deposition date: 2018-11-14, release date: 2019-09-18, Last modification date: 2023-10-11) |
Primary citation | Spangenberg, E.,Severson, P.L.,Hohsfield, L.A.,Crapser, J.,Zhang, J.,Burton, E.A.,Zhang, Y.,Spevak, W.,Lin, J.,Phan, N.Y.,Habets, G.,Rymar, A.,Tsang, G.,Walters, J.,Nespi, M.,Singh, P.,Broome, S.,Ibrahim, P.,Zhang, C.,Bollag, G.,West, B.L.,Green, K.N. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun, 10:3758-3758, 2019 Cited by PubMed: 31434879DOI: 10.1038/s41467-019-11674-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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